The Anticonvulsant Valproate Increases the Turnover Rate of γ-Aminobutyric Acid Transporters
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چکیده
منابع مشابه
The Anticonvulsant Valproate Increases the Turnover Rate of -Aminobutyric Acid Transporters*
Valproate is an important anticonvulsant currently in clinical use for the treatment of seizures. We used electrophysiological and tracer uptake methods to examine the effect of valproate on a -aminobutyric acid (GABA) transporter (mouse GAT3) expressed in Xenopus laevis oocytes. In the absence of GABA, valproate (up to 50 mM) had no noticeable effect on the steady-state electrogenic properties...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m207582200